It contains no bacteriostat, antimicrobial agent or added buffer. Infusing high concentrations of phosphate may result in a reduction of serum calcium and symptoms of hypocalcemic tetany. Use with caution in patients with renal impairment, cirrhosis, cardiac failure or in conjunction with other edematous medications. To avoid phosphate intoxication, infuse solutions containing sodium phosphate slowly. The concomitant amount of sodium (4 mEq/mL) must be calculated into total electrolyte dose of such prepared solutions. In the event of overdosage, discontinue infusions containing sodium phosphate immediately and institute corrective therapy to restore depressed serum calcium and to reduce elevated serum sodium levels. On the other hand, adrenal secretion of aldosterone increases renal tubular reabsorption of sodium in an effort to re-establish normal serum sodium concentration. In the 5 mL and 15 mL product, phosphoric acid and/or NaOH may have been added for pH adjustment. Vaccine ingredients and production in other nations are substantially the same. The vials marked with ‘‘PX’’ are partially filled to facilitate transfer of the contents. Each mL provides 3 mmol of phosphorus and 4 mEq sodium. Sodium Phosphates, USP, monohydrate monobasic is chemically designated NaH 2PO 4 • H 2O. It has been suggested that patients receiving TPN receive 20 mEq phosphate (13 mmol phosphate)/1000 kcal from dextrose. It comprises more than 90% of the total cations at its normal plasma concentration of approximately 142 mEq/L. only after dilution and thorough mixing in a larger volume of fluid. WARNING: This product contains aluminum that may be toxic. Both salts are colourless solids. Tissue loading may occur at even lower rates of administration. sodium phosphate, monobasic, monohydrate injection, solution, We comply with the HONcode standard for trustworthy health information -. In patients on TPN, approximately 10 to 15 mmol of phosphorus (equivalent to 310 to 465 mg elemental phosphorus) per liter bottle of TPN solution is usually adequate to maintain normal serum phosphate, though larger amounts may be required in hypermetabolic states. Serum phosphate levels should be regularly monitored and appropriate amounts of phosphate should be added to the infusions to maintain normal serum phosphate levels. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Monobasic Sodium Phosphate and Dibasic Sodium Phosphate Tablets. When serum sodium concentration is low, the secretion of antidiuretic hormone (ADH) by the pituitary is inhibited, thereby preventing water reabsorption by the distal renal tubules. Because many drugs are excreted in human milk, caution should be exercised when sodium phosphate is administered to a nursing woman. Sodium Phosphates Injection, USP is indicated as a source of phosphate, for addition to large volume intravenous fluids, to prevent or correct hypophosphatemia in patients with restricted or no oral intake. Dosage Form: injection, solution. The amount of sodium which accompanies the addition of phosphate also should be kept in mind, and if necessary, serum sodium levels should be monitored. The solution is intended as an alternative to potassium phosphate to provide phosphate ion (PO 4 3-) for addition to large volume infusion fluids for intravenous use. The ratio of disodium phosphate and monosodium phosphate in the extracellular fluid is 4 to 1 (80% to 20%) at the normal pH of 7.4. Also listed are substances used in the manufacturing process.[1]. Many modifying influences tend to alter the amount excreted in the urine. Expected supply: 19 … Phosphate, a predominant intracellular anion, plays an important role in energy storage, osteoblastic and osteoclastic activities, regulating serum calcium concentrations and numerous cellular phosphate-transfer reactions.. Potassium phosphate … Caution must be exercised in the administration of parenteral fluids especially those containing sodium ion, to patients receiving corticosteroids or corticotropin. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. These vials are flip-top, Single Dose Vials, packaged 25 vials per tray. FOR ADDITIVE USE ONLY AFTER DILUTION IN IV FLUIDS. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. AUST R: 16263. It must not be administered undiluted. For further information about unapproved drugs, click here. In patients with diminished renal function, administration of solutions containing sodium ions may result in sodium retention. Sodium Phosphates Injection, USP, 3 mmol/mL (millimoles/mL), is a sterile, nonpyrogenic, concentrated solution containing a mixture of monobasic sodium phosphate and dibasic sodium phosphate in Water for Injection. Generic Name: sodium phosphate, monobasic, monohydrate and sodium phosphate, dibasic, anhydrous An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. It is also not known whether sodium phosphate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. /Sodium phosphate, monobasic, monohydrate and sodium phosphate, dibasic anhydrous/ FDA/CDER; FDA Alert: Oral Sodium Phosphate (OSP) Products for Bowel Cleansing (marketed as Visicol and OsmoPrep, and oral sodium phosphate products available without a … Intravenous infusion of inorganic phosphate may be accompanied by a decrease in the serum level and urinary excretion of calcium. Plasma phosphate is believed to be filterable by the renal glomeruli, and the major portion of filtered phosphate (greater than 80%) is actively reabsorbed by the tubules. This buffer ratio varies with the pH, but owing to its relatively low concentration, it contributes little to the buffering capacity of the extracellular fluid. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum. PACKAGE LABEL - PRINCIPAL DISPLAY PANEL - Sodium Phosphates 15 mL Single Dose Vial Label, MiraLAX, Colace, docusate, senna, magnesium oxide, bisacodyl, erythromycin, polyethylene glycol 3350, Dulcolax. It is also useful as an additive for preparing specific parenteral fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. 26 August 2014 v0.12. Phosphate, present in large amounts in erythrocytes and other tissue cells, plays a significant intracellular role in the synthesis of high energy organic phosphates. Occurs as white, odorless crystals or granules freely soluble in water. Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA, This page was last edited on 5 February 2021, at 18:59. Frequent monitoring of serum calcium and sodium as well as renal function is recommended. Phosphate intoxication results in a reduction of serum calcium and the symptoms are those of hypocalcemic tetany (see WARNINGS). The solution is intended as an alternative to potassium phosphate to provide phosphate ion (PO 43-) for addition to large volume infusion fluids for intravenous use. Sodium phosphate is contraindicated in diseases where high phosphate or low calcium levels may be encountered, and in patients with hypernatremia. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. The solution is administered after dilution by the intravenous route as an electrolyte replenisher. 0.08 mg potassium phosphate monobasic 0.45 mg sodium phosphate dibasic Sodium phosphate monobasic, trace amounts: Phosphate Buffer: Buffer: Zostavax: Varicella Zoster: 0.10 mg potassium phosphate monobasic 0.57 mg sodium phosphate monobasic: Polydimethylsiloxane: Anitfoam: Typhim Vi: Typhoid: Fatty-acid ester-based antifoam …

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